Oncolytic viruses

Other oncolytic viruses exist, and it is even possible to make new viruses by changing the existing order to obtain the required properties. The strain of measles, but major benefits: used since the late 60s, every year millions of children to be vaccinated is documented safety of its administration. Furthermore, the virus an anti-tumor activity "pitch": this will not only lead to damage to infect tumor cells, but it will be simultaneous activation of the cells of the immune system of the patient to fall well to the tumor. "The destruction of cancer cells by virus leads to the production of the warning signals, which are recognized by the immune system," Marc said Gregory. "The immune response, in particular, next to the tumor cells then in implementation. More data suggest that there is a plan immunological memory cell production." In this case, vaccines against the measles viruses not only destroy the tumor, but also to prevent recurrence again a tumor in the body; the immune attack cell is comparable. The last point is the control and DRS Gregory and spicy is not active.

The exploit of this virus, and further oncolytic viruses has previously been tested in clinical trials, mainly at the Mayo Clinic in Rochester (Minnesota,USA). U.S. test results are not yet published, but according to Marc Grégoire, they would rather encourage. Viruses tested at the Mayo Clinic to date would treat many types of cancer such as myeloma, gliomas, glioblastomas, ovarian carcinoma or even breast cancer. "We work on the model of mesothelioma [cancer of the pleura], but we are also looking forward to testing this approach on melanoma and lung cancers. The basic system is ready. There are still many details to be validated, but the use of oncolytic viruses as antitumor vaccine that against measles could start in a future not far."